Bupropion: What It Is and How to Use It

Bupropion is a common prescription medicine used to treat depression and to help people stop smoking. It works differently than many antidepressants and can boost energy and motivation for some people who felt numb on other drugs. Doctors also use it off‑label for ADHD and to help with sexual side effects from other antidepressants.

How should you take bupropion? Typical adult doses vary by formulation. For smoking cessation, the usual schedule starts at 150 mg once daily for three days, then 150 mg twice a day. For depression, immediate‑release tablets are often given 75 mg three times daily, sustained‑release 150 mg twice daily, and extended‑release 150–300 mg once daily. Doctors rarely exceed 450 mg per day because higher doses raise seizure risk. Swallow extended‑release tablets whole; do not crush or chew them.

When will it start working? Some people notice improved energy and sleep within one to two weeks, but mood benefits commonly take four to six weeks. Keep taking it as prescribed; stopping suddenly can cause problems, so talk to your prescriber before changing doses.

Common side effects include dry mouth, trouble sleeping, headache, and sweating. Less common but serious risks are seizures, allergic reactions, and worsening mood or suicidal thoughts, especially in young adults starting or changing doses. Risk factors for seizures include a history of seizures, eating disorders like bulimia, heavy alcohol use or sudden alcohol withdrawal, brain injury, and taking other drugs that lower the seizure threshold.

Drug interactions matter. Avoid taking monoamine oxidase inhibitors (MAOIs) within two weeks of bupropion. Tell your doctor about antipsychotics, other antidepressants, tramadol, stimulant medications, and medicines that affect liver enzymes; some combinations raise seizure risk or change bupropion levels.

Practical tips: take the earlier dose mid‑day or avoid the evening dose to reduce insomnia. If you miss a dose, take it when you remember unless it’s almost time for the next dose—don’t double up. Store at room temperature away from moisture. If you plan to drink heavily or stop drinking, check with your prescriber first.

Pregnancy and breastfeeding need a doctor’s talk. Some people use bupropion during pregnancy, but risks and benefits vary. Always discuss plans with your obstetrician or pediatrician.

Want to buy bupropion online? Use only licensed pharmacies that require a valid prescription and show clear contact information. Avoid sites offering large discounts without asking for a prescription—those could sell counterfeit or unsafe products.

If you experience seizures, allergic reactions (hives, swelling, trouble breathing), severe mood changes, or thoughts of self‑harm, seek medical help right away. For routine side effects or dose questions, call the clinic that prescribed the medicine.

Keep a simple log of how you feel during the first eight weeks. Note sleep changes, appetite, headaches, mood swings, and any missed cigarettes if you’re quitting. Bring this log to follow‑up visits so your doctor can adjust dose or switch medicines faster. Regular blood tests are not usually needed, but your clinician may check liver function or other tests based on other health conditions. Ask questions.