Nefazodone UK — what you should know now

Nefazodone is an older antidepressant that used to be prescribed for depression and anxiety. In the UK it’s uncommon today because of rare but serious liver problems linked to the drug. If you’ve heard about nefazodone and are wondering whether it’s a good option, this page gives clear, practical facts and safe steps you can take.

Where to get nefazodone in the UK

Nefazodone is prescription-only. That means a GP or psychiatrist has to assess you first. Many UK prescribers prefer newer antidepressants (SSRIs, SNRIs) because they have a more predictable safety profile. If a doctor thinks nefazodone might help, they’ll explain the risks and arrange baseline checks like liver function tests.

If you’re tempted to buy nefazodone online, don’t rush. Only use pharmacies registered with the General Pharmaceutical Council (GPhC) or recognised UK online services. Avoid unregulated overseas sites that sell without a prescription — pills from those sites can be fake or contaminated.

Safety, side effects and what to watch for

The main safety concern with nefazodone is liver injury. That’s why UK clinicians require liver tests before and during treatment. Other common side effects include drowsiness, dizziness, dry mouth and low blood pressure when standing up. Nefazodone also interacts with many medicines because it affects liver enzymes — tell your doctor about every drug, herbal remedy, or supplement you take.

Know the warning signs: dark urine, yellowing skin or eyes, severe tiredness, persistent stomach pain, or unexplained bleeding. If any of those appear, stop the drug and contact a doctor or NHS 111 immediately.

Alcohol increases liver strain and can make side effects worse. If you’re on nefazodone, limit or avoid alcohol and discuss safe levels with your clinician.

Pregnancy, breastfeeding and plans to conceive should be discussed before starting nefazodone. Some antidepressants are preferred in pregnancy; your prescriber will weigh risks and benefits for your situation.

If you’re switching from or to another antidepressant, follow a doctor’s plan. Sudden stops or starts can cause withdrawal symptoms or drug interactions. Your prescriber will plan gradual changes and monitor you closely.

Need practical next steps? Ask your GP for a full review of current meds, bring a list of what you take, and request liver tests if nefazodone is being considered. If you find a pharmacy online, check the GPhC registration and that they require a valid prescription before sending meds.

For reliable info, use NHS and MHRA resources or speak to your pharmacist. If your doctor recommends an alternative, common choices in the UK include SSRIs, SNRIs and other older options like trazodone or mirtazapine — each comes with its own pros and risks, so discuss which fits your symptoms and lifestyle.

Want help preparing for that GP appointment? Write down your symptoms, past medication responses, any liver disease history, and questions about side effects — it makes the conversation quicker and safer.