Roflumilast (brand name Daliresp) is an oral medicine used mainly for severe COPD with chronic bronchitis and frequent flare-ups. Unlike inhalers that open airways, roflumilast cuts lung inflammation by blocking an enzyme (PDE4). That makes it an add-on for people who still have attacks despite inhaled treatments.
Roflumilast lowers inflammation in the lungs, which can reduce the number of exacerbations. Doctors typically consider it for adults with severe COPD, chronic bronchitis symptoms, and a history of exacerbations despite proper use of long-acting bronchodilators or inhaled steroids. It’s not a rescue drug — don’t use it for sudden breathing trouble.
Dosing is usually one 500 mcg tablet once a day. Take it at the same time each day. If you miss a dose, take it when you remember unless it’s close to the next dose; don’t double up.
Common side effects are gastrointestinal: diarrhea, nausea, and weight loss happen most often. Some people report headache, decreased appetite, or trouble sleeping. There are also reports of mood changes, anxiety, or worsening depression. If you have a history of depression or suicidal thoughts, mention that to your clinician before starting roflumilast.
Check your weight regularly. Unexpected weight loss can be a sign the drug isn’t tolerable. If side effects are severe or mood changes appear, call your doctor — you may need to stop the medicine.
Roflumilast is processed by liver enzymes (CYP3A4 and CYP1A2). Strong inhibitors like ketoconazole can raise drug levels. Strong inducers like rifampin can lower levels and reduce effectiveness. Tell your doctor about all meds, supplements, and even herbal products like St. John's wort.
Pregnancy and breastfeeding data are limited. If you are pregnant, planning pregnancy, or nursing, discuss risks and alternatives with your clinician.
This medicine is prescription-only. Don’t buy from sites that won’t require a prescription. If using an online pharmacy, choose reputable services and keep a record of prescriptions and labels.
Roflumilast isn’t a replacement for inhaled bronchodilators or steroids. Think of it as an add-on for specific COPD patients who keep having exacerbations. Talk openly with your respiratory specialist about how it fits into your treatment plan.
Quick checklist: one 500 mcg tablet daily, watch for diarrhea and weight loss, report mood changes, avoid strong CYP3A4/1A2 interactions, and keep regular follow-ups. Ask your clinician how roflumilast compares with other options for your case — the right choice depends on symptoms, other meds, and overall health.
As a career-driven individual, I understand the importance of balancing work and health. Recently, I came across Roflumilast, a medication that helps people with chronic obstructive pulmonary disease (COPD). It made me realize how crucial it is to prioritize our health while chasing professional goals. After all, a healthy body and mind can lead to better work performance and overall satisfaction. So let's keep striving for success without compromising our well-being!
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