Nevirapine: Uses, Side Effects, and What You Need to Know

When treating HIV, nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to block HIV replication. Also known as Viramune, it's often part of first-line combination therapy for people starting antiretroviral treatment. Unlike some HIV drugs that require injections, nevirapine comes as a pill, making it easier to take daily. But it’s not without risks—some people develop serious skin rashes or liver problems, especially in the first 18 weeks. That’s why doctors usually start with a low dose and watch closely.

Nevirapine works by targeting the HIV enzyme reverse transcriptase, which the virus needs to copy its genetic material. Without it, the virus can’t multiply. It’s often paired with other drugs like tenofovir or emtricitabine to reduce the chance of resistance. But you can’t use nevirapine alone—it’s never a solo treatment. If you’ve had liver disease before, or if you’re a woman with a CD4 count over 250, your doctor may avoid nevirapine because the risk of liver damage goes up. It’s also not recommended during pregnancy unless no other options exist, due to potential harm to the baby.

People on nevirapine often report headaches, fatigue, or nausea at first, but these usually fade. The big red flags are blistering skin, yellow eyes, dark urine, or fever with a rash—call your doctor right away if you see any of those. Many of the posts below dive into how HIV meds like nevirapine interact with other drugs, how to spot dangerous side effects early, and what alternatives exist when nevirapine isn’t safe. You’ll also find comparisons with other NNRTIs like efavirenz, and how liver health affects how these drugs are processed in your body. Whether you’re starting treatment, switching meds, or just trying to understand what’s in your pill bottle, the guides here give you real, practical info—not just theory.

Below, you’ll find real-world advice on managing HIV medications, spotting dangerous reactions, and choosing safer alternatives when needed. These aren’t generic overviews—they’re detailed, patient-tested insights from people who’ve been there.